Thank you for the quick reply!
I finally realized this as well, late last night after re-reading the set up guide (wasn't clear on first read). Both X2 and X4 need to be wired up in order for the DIO to function properly. Otherwise it's either comms or pin power, but not both.

I am new to RevPi, and am just setting up the hardware. I have gone through the configuration with Pictory, added the DIO on the right side, made sure my firmware is up to date.
I am using Core S and a single DIO, with Pybridge.

When using Node Red, I can see my DIO pins (both input and output) in ...